脊髓损伤是中枢神经系统的严重损伤，目前尚缺乏有效的治疗。近年来发现脊髓室管膜区存在内源 性神经干细胞（ENSCs）具有促进脊髓损伤修复的潜力。脊髓损伤及微环境改变等可使脊髓室管膜区的 ENSCs激活、增殖、分化，进一步修复受损的神经结构。虽然脊髓室管膜区ENSCs在脊髓损伤修复中具有 积极作用，但其机制尚无定论。本文对脊髓室管膜区ENSCs在脊髓损伤修复中潜在作用机制进行综述，为 基础和临床领域全面认识脊髓室管膜区ENSCs提供参考。

Spinal cord injury is a serious injury of the central nervous system, and there is currently a lack of effective treatment. In recent years, it has been found that endogenous neural stem cells (ENSCs) in ependymal region of spinal cord have the potential to promote the repair of spinal cord injury. Spinal cord injury and microenvironment changes can promote the activation, proliferation, and differentiation of ENSCs in the ependymal region of the spinal cord, which helps to repair damaged neural structures. Although ENSCs play a positive role in the repair of spinal cord injury, the mechanism remains inconclusive. This article reviews the potential mechanism of spinal cord ependymal region ENSCs in the repair of spinal cord injury, providing more data to know the function of ENSCs in ependymal region of spinal cord from both basic and clinical perspective.