目的：评估新型冠状病毒肺炎疫情对武汉一线医护人员脑功能和心理健康的影响。方法：临床一线 医务人员141例，在疫情期间和疫情结束后采用症状自评量表（SCL-90）进行评定，同时采用北京易飞华通 公司研制的脑功能仪检测脑健康状况。结果：疫情期间一线医护人员的 SCL-90 总分明显高于疫情后 （[ 145.4±42.8）和（131.4±35.3）分，P＜0.05]，SCL-90因子分≥2分的人数分布较多的因子是躯体化、抑郁和 偏执。脑功能监测指标中，脑能耗、脑放松、脑惰性和脑稳定等项目在疫情期间测得数值明显高于疫情后 （P＜0.05）。结论：新型冠状病毒肺炎疫情给武汉一线医护人员带来巨大压力，导致脑功能监测异常和心理 障碍。

To evaluate cerebral function and mental health of frontline medical staff during the COVID-19 pandemic in Wuhan. Methods: A total of 141 frontline health workers were enrolled. The Symptom Checklist-90 (SCL-90) was used to assess the mental health of the medical staff. The brain function of the medical staff was evaluated by a cerebral functional device produced by Beijing Easymonitor Tech. Results: During the COVID-19 outbreak, the total SCL-90 scores of frontline medical staff were significantly higher than scores after the pandemic [(145.4 ± 42.8) versus (131.4 ± 35.3), P<0.05)]. The positive mental symptoms (SCL-90 factors ≥2) were somatization, depression, and paranoia. Analysis of cerebral functions showed that factors such as brain metabolism rate, brain relaxation, cognitive efficiency, and mental resilience were significantly higher during the COVID-19 pandemic than after. Conclusion: The COVID-19 pandemic brought immense pressure to the frontline medical staff in Wuhan, leading to abnormal brain function and mental health disturbances.