目的：探讨不同年龄层次的2型糖尿病并发周围神经病变（DPN）患者的危险因素的差异。方法：2 型糖尿病患者178例纳入研究。根据有无并发周围神经病变，分为非DPN组54例和DPN组124例；再根 据年龄差异将124例DPN组分为老年DPN组（年龄≥60岁）和普通DPN组（年龄＜60岁）；收集各组一般 资料及血液检测结果，并进行统计分析。结果：非DPN组和DPN组患者的年龄、糖尿病病程、糖化血红蛋 白（HbA1c）、2 h餐后血糖（PG）、3 h PG、尿微量白蛋白（ALB）、尿肌酐（UCr）、尿A/C差异有统计学意义（均 P＜0.05）；Logistic多因素回归分析显示患者的年龄、糖尿病病程是发生DPN的影响因素。非DPN组、普 通DPN组和老年DPN组的年龄、HbA1c、3h PG、Cr、尿A/C差异均有统计学意义（均P＜0.05）；老年DPN组 和普通DPN组患者的Cr和尿A/C差异均有统计学意义（均P＜0.05）。结论：年龄及糖尿病病程是2型糖尿 病并发DPN的影响因素；老年DPN患者出现糖尿病肾病的几率会增大。

To investigate the risk factors of diabetic peripheral neuropathy (DPN) in patients with type 2 diabetes mellitus (T2DM) in different age groups. Methods: A total of 178 patients with T2DM were recruited. Patients were divided into the Non-DPN group (54 cases) and DPN group (124 cases) based on the absence or presence of DPN. The DPN group was further divided into the elderly (≥60 years old) and general (＜ 60 years old) subgroups according to age. Data were compared between the two groups, and results were statistically analyzed. Results: Between the DPN group and Non-DPN group, the age, course of disease, and levels of HbA1c, 2hr postprandial glucose (PG), 3hr PG, urinary microalbumin (ALB), urinary creatinine (Cr), and urinary A/C were significantly different (all P＜0.05). Logistic regression analysis showed that age and course of disease were significantly correlated with DPN occurrence. There were statistically significant differences in the age, HbA1c, 3hr PG, Cr, and urinary A/C between the Non-DPN, standard DPN, and elderly DPN groups (all P＜0.05). There was a significant difference between the elderly and standard DPN groups in Cr and urinary A/C (both P＜0.05). Conclusion: Age and course of disease are the risk factors for DPN occurrence in patients with T2DM. Elderly DPN patients are at an increased risk for developing diabetic kidney disease.