目的：应用静息态功能磁共振成像技术对双相躁狂的患者进行研究，以期为双相躁狂病理生理机制研 究提供基础。方法：运用局部一致性（ReHo）和低频振幅（ALFF）分析比较19例双相躁狂患者和22例健康对 照的静息态功能磁共振数据，并将双相躁狂的差异脑区ReHo值和ALFF分别与年龄、总病程、受教育年限和 贝克-拉范森躁狂量表（BRMS）评分进行Pearson相关分析。结果：与正常对照组相比，双相躁狂患者在右侧额 中回及右侧角回ReHo降低，左侧楔前叶及双侧尾状核ALFF升高。双相躁狂患者右侧额中回ReHo值与年龄 存在显著负相关（P=0.0143, r=－0.5520），其余差异脑区与年龄、总病程、受教育年限和BRMS评分均无明显 相关。结论：双相躁狂患者在右侧额中回、右侧角回、左侧楔前叶及双侧尾状核存在功能异常。

The resting state functional magnetic resonance imaging (fMRI) technique was used to study the patients with bipolar mania, which provides a research basis for the pathophysiological mechanism of bipolar mania. Methods: Resting fMRI data from 19 bipolar mania patients and 22 healthy controls were analyzed by using Regional homogeneity (ReHo) and amplitude of low-frequency fluctuation (ALFF)，and Pearson correlation analysis was performed between the differences in brain regions ReHo and ALFF, age, total course of disease, years of education, and BRMS score. Results: Compared with the normal control group, patients with bipolar mania had decreased ReHo in the right medial frontal gyrus and right angular gyrus. ALFF was elevated in the left precuneus and bilateral caudate nucleus. In patients with bipolar mania, there was a significant negative correlation between the right median frontal gyrus ReHo value and age (P=0.0143, r=－0.5520), while there was no significant correlation between other brain regions and age, total course of disease, years of education and BRMS score. Conclusion: Patients with bipolar mania have functional abnormalities in the right middle frontal gyrus, right angular gyrus, left precuneus and bilateral caudate nucleus.