目的：探讨精神分裂症患者的认知功能损害的性别差异。方法：精神分裂症患者55例纳入病例组，与 其匹配的健康对照者55例纳入对照组，使用精神分裂症认知功能简明成套测评量表（BACS）来评估2组的 认知功能，探讨病例组神经认知功能的性别差异。结果：病例组的BACS 6项分测试得分均显著低于对照 组（P＜0.01）；病例组中的男性亚组在言语流畅性任务的得分显著低于女性亚组（P＜0.05）。结论：精神分 裂症患者存在显著的认知功能损害，且男性患者的言语流畅性认知损害较女性患者更加严重。

To investigate the gender differences in cognitive function impairment in patients with schizophrenia. Methods: Fifty-five patients with schizophrenia and 55 healthy controls were recruited and assigned to the schizophrenia group and control group, respectively. The Brief Assessment of Cognition in Schizophrenia (BACS) was used to evaluate cognitive function in both groups. Subsequent, we investigated gender differences in cognitive function in the schizophrenia group. Results: The schizophrenia group scored significantly lower than the control group on all 6 cognitive tests in the BACS (P<0.01). Within the schizophrenia group, the performance of male patients on the verbal fluency test was much lower than that of female patients (P< 0.05). Conclusion: This study shows that patients with schizophrenia suffer significant cognitive impairment. Furthermore, male schizophrenic patients show a greater impairment in verbal fluency than female patients.