目的：研究脑梗死患者颅内动脉狭窄负荷的危险因素。方法：颅内动脉粥样硬化狭窄（ICAS）的脑梗 死患者280例纳入研究，经头颅320CTA或MRA明确颅内动脉狭窄支数及动每支脉狭窄的程度。根据动脉 狭窄数量分为单支动脉狭窄组102例和多支动脉狭窄组178例；以颅内动脉狭窄评分作为评价狭窄程度的 标准，分为颅内动脉狭窄低分组126例和高分组154例；分别对其危险因素进行分析。结果：高血压、糖尿 病、高脂血症、卒中家族史及高同型半胱氨酸血症与颅内动脉狭窄负荷呈正相关（P＜0.05）；高血压、糖尿 病、卒中家族史、高同型半胱氨酸血症为多支动脉狭窄（OR=4.900、3.139、1.945、1.861）与动脉狭窄高分组 （OR=4.900、3.139、1.945、1.86）的独立危险因素。结论：高血压、糖尿病、卒中家族史及高同型半胱氨酸血症 为颅内动脉狭窄负荷的独立危险因素，这4种危险因素均能使颅内动脉狭窄支数增多及狭窄程度增加。 关键词 颅内动脉狭窄；动脉粥样硬化；危险因素

To study the risk factors of intracranial artery stenosis (ICAS) burden in patients with cerebral infarction. Methods: A total of 280 patients with cerebral infarction and ICAS were included in the study. The number of ICAS and the degree of stenosis in each branch were confirmed by head 320 CTA or MRA. All patients were divided into the single artery stenosis group (n=102) or multiple artery stenosis group (n=178) according to the number of artery stenosis. Intracranial artery stenosis score was used to evaluate the degree of stenosis, and according to this score, all patients were divided into the low score stenosis group (n=126) or high score stenosis group (n=154). The risk factors for stenosis were analyzed. Results: Hypertension, diabetes, hyperlipidemia, family history of stroke, and hyperhomocysteinemia were positively correlated with ICAS (P< 0.05). Hypertension, diabetes, family history of stroke, and hyperhomocysteinemia were independent risk factors for multiple artery stenosis (OR=4.900, 3.139, 1.945, 1.861) and high score stenosis (OR=4.900, 3.139, 1.945, 1.86). Conclusion: Hypertension, diabetes, family history of stroke, and hyperhomocysteinemia are independent risk factors for ICAS burden. These four risk factors can increase the number and degree of ICAS.