目的：观察光刺激对3xTg阿尔茨海默病（AD）模型小鼠海马长时程增强（LTP）及β淀粉样蛋白（Aβ）的 影响。方法：4～6月3xTg AD小鼠20只随机分为光刺激（PS）组，未刺激（NS）组，同背景野生型小鼠10只为 对照组。PS组小鼠接受2 Hz光刺激4周，其余2组正常环境饲养。4周后断头取脑，制作离体脑片，诱导海 马LTP，并检测小鼠海马组织内Aβ蛋白含量。结果：NS组小鼠LTP明显受抑，海马组织内Aβ含量较对照组 明显升高（P＜0.05）。PS 组小鼠较 NS 组小鼠海马 Aβ蛋白水平明显降低（P＜0.05），LTP 明显增强（P＜ 0.05）。结论：光刺激增强3xTg AD模型小鼠海马LTP，降低海马Aβ含量。

To observe the effect of photic stimulation on long term potentiation (LTP) and A beta in the hippocampus of 3xTg Alzheimer's model mice. Methods: Twenty 4～6 month 3xTg AD mice were randomly divided into photic stimulation (PS) group and unstimulated (NS) group. Ten wild type mice in the same background were in the control group. AD mice in the PS group received 2 Hz photic stimulation for 4 weeks. After the mice were decapitated, the in vitro hippocampal LTP was induced and the A beta protein content in the hippocampus of mice was detected. Results: The LTP of mice in NS group was significantly inhibited, and the content of A beta in the hippocampus was significantly higher than that in control group (both P<0.05). The level of A beta protein in hippocampus of mice in PS group was significantly lower than that in NS group, while LTP increased significantly (both P<0.05). Conclusion: Photic stimulation enhanced the hippocampal LTP and reduced the content of A beta in 3xTg AD mice model