目的：分析大动脉粥样硬化型缺血性脑卒中（LAA-IS）患者185 例中SLCO1B1 基因388A＞G 和 521T＞C多态性位点的分布。方法：LAA-IS患者185 例纳入研究，通过聚合酶链反应-荧光探针方法对其外 周血样本中SLCO1B1 基因的388G＞A和521T＞C位点进行检测并统计分析其基因分型分布。结果：根据 SLCO1B1 基因多态性分型，185 例LAA-IS 患者中SLCO1B1 基因388A＞G位点纯合野生型占8.6%，杂合突 变型占40.5%，纯合突变型占50.8%；521T＞C位点纯合野生型占77.8%，杂合突变型占21.0%，纯合突变型 占1.1%。结论：本组185 例LAA-IS患者中分布有较多的突变型SLCO1B1基因。

To analyze the distribution of the SLCO1B1 gene 388A＞G and 521T＞C polymorphic loci in 185 patients with large artery atherosclerosis-subtype ischemic stroke (LAA-IS). Methods: This study recruited 185 LAA-IS patients as research subjects. The 388G>A and 521T>C loci of the SLCO1B1 gene in the peripheral blood samples were detected by the polymerase chain reaction fluorescence probe method, and the distribution of their genotyping was statistically analyzed. Results: According to the polymorphism of the SLCO1B1 gene in the 185 LAA-IS patients, at the 388A>G site, homozygous wild type accounted for 8.6%, heterozygous mutant type accounted for 40.5%, and homozygous mutant type accounted for 50.8%; at the 521T> C site, homozygous wild type accounted for 77.8% , heterozygous mutant type accounted for 21.0% , and homozygous mutant type accounted for 1.1%. Conclusion: Within the 185 cases in this study, there exists a large distribution of mutant genotypes of the SLCO1B1 gene.