热休克蛋白（Heat Shock Proteins，HSPs）作为人体内一类重要的分子伴侣蛋白，可参与调控多种病理 生理过程，在维持人体健康中发挥重要作用。随着对其研究不断深入，发现HSPs在帕金森病（Parkinson's disease，PD）中发挥重要的调节作用，逐渐成为治疗这一神经退行性疾病的关键靶点。笔者对HSPs通过影 响α-突触核蛋白（Alpha-Synuclein，α-Syn）聚集、线粒体功能与氧化应激、细胞的自噬、细胞的凋亡及神经炎 症等参与PD的病理机制进行综述，旨在为PD治疗提供新的研究和临床应用方向。

Heat Shock Proteins (HSPs), as a crucial class of molecular chaperones in the human body, participate in the regulation of various pathophysiological processes and play a vital role in maintaining human health. With the deepening of research, HSPs have been found to exert significant regulatory effects in Parkinson's disease (PD), gradually emerging as a key therapeutic target for this neurodegenerative disorder. This article summarizes the pathological mechanisms through which HSPs are involved in PD by influencing alpha-synuclein ( α-Syn) aggregation, mitochondrial function and oxidative stress, cellular autophagy, apoptosis, and neuroinflammation, aiming to provide new research and clinical application directions for PD treatment.