摘要
目的:构建结构方程模型,分析运动习惯对帕金森病轻度认知障碍的影响路径。方法:通过横断面
研究,选择2021年10月至2023年6月期间在北京市解放军总医院帕金森病门诊就诊的PD患者151例,采
用一般资料问卷、蒙特利尔认知评估量表(MoCA)、国际统一帕金森评定量表第三部分(UPDRS-Ⅲ)、帕金
森睡眠量表-2(PDSS-2)、汉密尔顿抑郁量表(HAMD)对患者进行调查。采用Mplus 8.3软件进行关联路径
分析。结果:运动习惯与PD-MCI诊断风险之间的直接与间接关联路径均显著(P<0.05),包括运动习惯
→PD-MCI(-0.153[-0.305, -0.006])、运动习惯→运动症状→PD-MCI(-0.070[-0.129, -0.029])、运动
习惯→运动症状→抑郁症状→PD-MCI(-0.025[-0.051, -0.011])、运动习惯→运动症状→睡眠质量→
PD-MCI(-0.011[-0.028, -0.003])、运动习惯→抑郁症状→PD-MCI(-0.030[-0.067, -0.005])。结论:
运动习惯可直接预测PD-MCI的诊断风险,亦可以分别通过运动症状、抑郁症状中介作用,以及运动症状
与抑郁症状或者睡眠质量结合的链式中介效应间接预测PD-MCI的诊断风险。
Abstract
To construct a structural equation model and analyze the impact pathways of exercise
habits on mild cognitive impairment in Parkinson disease (PD-MCI). Methods: A cross-sectional study was
conducted, involving 151 PD patients who visited the Parkinson's Disease Clinic at the Chinese PLA General
Hospital in Beijing from October 2021 to June 2023. Patients were surveyed using a general information
questionnaire, the Montreal Cognitive Assessment (MoCA), Part III of the Unified Parkinson's Disease Rating
Scale (UPDRS- Ⅲ), the Parkinson's Disease Sleep Scale-2 (PDSS-2), and the Hamilton Depression Scale
(HAMD). Mplus 8.3 software was used for association pathway analysis. Results: Both direct and indirect
association pathways between exercise habits and the diagnostic risk of PD-MCI were significant (P<0.05).
These pathways included: exercise habits→PD-MCI(-0.153[-0.305, -0.006]), exercise habits→motor symptoms→PD-MCI(- 0.070[- 0.129, - 0.029]), exercise habits→motor symptoms→depressive symptoms→
PD-MCI(-0.025[-0.051, -0.011]), exercise habits→motor symptoms→sleep quality → PD-MCI(-0.011
[-0.028, -0.003]), and exercise habits→depressive symptoms→PD-MCI(-0.030[-0.067, -0.005]). Conclusion: Exercise habits can directly predict the diagnostic risk of PD-MCI. They can also indirectly predict
the diagnostic risk of PD-MCI through the mediating effects of motor symptoms and depressive symptoms, as
well as through the chained mediating effects of motor symptoms combined with depressive symptoms or sleep
quality.
关键词
帕金森病;轻度认知障碍;运动;路径分析
Key words
Parkinson disease; mild cognitive impairment; exercise; path analysis
汤若男1
,王淼1
,尹西1
,王振福1
,高中宝1
,王玉玲2.
运动习惯与帕金森病轻度认知障碍的关联路径分析[J]. 神经损伤与功能重建. 2026, 21(5): 255-260 https://doi.org/10.16780/j.cnki.sjssgncj.20240707
TANG Ruonan1
,WANG Miao1
,YIN Xi1
,WANG Zhenfu1
,GAO Zhongbao1
,WANG Yuling2.
Analysis of the Association Pathways Between Exercise Habits and Mild CognitiveImpairment in Parkinson Disease[J]. Neural Injury and Functional Reconstruction. 2026, 21(5): 255-260 https://doi.org/10.16780/j.cnki.sjssgncj.20240707
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