目的：使用功能性近红外光谱（fNIRS）技术分析卒中患者与健康对照组在静息态和任务态下的大脑
皮质氧合变化。方法：纳入27例脑卒中患者（卒中组）和15例健康对照者（健康对照组）。通过fNIRS设备
采集静息态和言语流畅性任务（VFT）期间的脑部血氧变化数据。结果：静息态分析显示，卒中组在涉及多
个脑区的 26 组通道的功能连接强度较健康对照组较高，提示卒中组可能存在过度激活和代偿机制。在
VFT 任务态下，卒中组在右侧 DLPFC、右侧 Broca 区和左侧 SSC 的激活高于健康对照组（P＜0.05）。右侧
DLPFC、右侧Broca区血氧浓度存在差异（P＜0.05），而左侧SSC未见明显差异。结论：静息态和任务态下的
大脑功能变化反映了卒中后大脑的去抑制与代偿机制，表明卒中组的大脑网络功能可能存在不同的神经适
应和重组现象。
To analyze the cerebral cortical oxygenation changes in stroke patients and healthy
controls during resting-state and task-state conditions using functional near-infrared spectroscopy (fNIRS)
technology. Methods: A total of 27 stroke patients (stroke group) and 15 healthy controls (healthy control
group) were included. Brain oxygenation changes during resting-state and the Verbal Fluency Task (VFT) were
collected using an fNIRS device. Results: Resting-state analysis revealed that the functional connectivity
strength across 26 channels involving multiple brain regions was higher in the stroke group compared to the
healthy control group, suggesting possible hyperactivation and compensatory mechanisms in the stroke group.
During the VFT task-state, the stroke group exhibited higher activation in the right dorsolateral prefrontal cortex
(DLPFC), right Broca's area, and left somatosensory cortex (SSC) compared to the healthy control group (P<
0.05). Significant differences in oxygen concentration were observed in the right DLPFC and right Broca's area
(P<0.05), while no significant difference was found in the left SSC. Conclusion: The cerebral functional
changes observed during resting-state and task-state conditions reflect disinhibition and compensatory
mechanisms in the brain following stroke, indicating that the stroke group may exhibit distinct neural adaptation
and reorganization phenomena in brain network function.
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