进行性非流利性失语（progressive non-fluent aphasia，PNFA）是一种神经退行性疾病，属于原发性进行性 失语的一种临床亚型，特征为语言表达逐渐缓慢、断续且语法错误增多。现有研究显示，PNFA主要与tau蛋白 和TAR DNA结合蛋白43（TAR DNA binding protein-4，TDP-43）蛋白异常相关，并可能涉及多重蛋白病理。在 诊断方面，研究者利用磁共振成像、正电子发射断层扫描和放射组学等影像学技术发现PNFA患者存在特定的 脑结构改变，为早期诊断提供了依据。在治疗方面，言语及语言治疗和非侵入性脑刺激技术（如经颅直流电刺 激、经颅磁刺激）显示出一定的改善效果，但目前药物治疗进展有限。

Progressive non-fluent aphasia (PNFA) is a neurodegenerative disease, a clinical subtype of primary progressive aphasia, characterized by gradually slowing, intermittent language expression and increasing grammatical errors. Current studies have shown that PNFA is mainly associated with abnormalities in tau protein and TAR DNA binding protein-43 (TDP-43), and may involve multiple protein pathologies. In terms of diagnosis, researchers have used imaging techniques such as magnetic resonance imaging (MRI), positron emission tomography (PET), and radiomics to discover specific brain structural changes in patients with PNFA, providing a basis for early diagnosis. In terms of treatment, speech and language therapy and non-invasive brain stimulation techniques (such as transcranial direct current stimulation and transcranial magnetic stimulation) have shown certain improvement effects, but the progress of pharmacotherapy is currently limited.