帕金森病是一种中枢神经系统退行性疾病，常合并多种非运动症状，认知功能障碍是其重要的非运动 症状，严重影响患者生活质量，但帕金森病伴认知障碍的发病机制尚不明确。血脑屏障的破坏被认为介导 和参与帕金森病及帕金森病伴认知障碍，并且影响病程进展。S100钙结合蛋白B 、闭合蛋白、封闭蛋白-5、 水通道蛋白-4、胶质纤维酸性蛋白、基质金属蛋白酶-9均为反映血脑屏障破坏的标志物，同时在帕金森病及 帕金森病伴认知障碍的病理生理过程中也扮演重要角色。本文将阐述这些特异性蛋白作为血脑屏障破坏 的外周生物标志物以及与帕金森病、帕金森病伴认知障碍发展之间的相关性研究进展。

Parkinson's disease is a degenerative disorder of the central nervous system, often accompanied by a variety of non-motor symptoms. Cognitive dysfunction is a significant non-motor symptom that severely impairs patients' quality of life. However, the pathogenesis of Parkinson's disease with cognitive impairment remains unclear. The disruption of the blood-brain barrier is believed to mediate and participate in the development of Parkinson's disease and Parkinson's disease with cognitive impairment, and it also influences disease progression. S100 calcium-binding protein B, occludin, claudin-5, aquaporin-4, glial fibrillary acidic protein, and matrix metalloproteinase-9 are all biomarkers reflecting blood-brain barrier disruption, and they also play crucial roles in the pathophysiological processes of Parkinson's disease and Parkinson's disease with cognitive impairment. This article will elaborate on the research progress regarding these specific proteins as peripheral biomarkers of blood-brain barrier disruption and their correlation with the development of Parkinson's disease and Parkinson's disease with cognitive impairment.