铜死亡（Cuprotosis）是近年来新发现的一种细胞死亡方式，阿尔茨海默病（Alzheimer's Disease，AD） 是一种起病隐匿呈进行性发展的中枢神经系统退行性疾病。铜参与AD的多种发病机制，铜失衡可通过这 些不同机制诱导神经细胞及胶质细胞的死亡，以此来导致AD的发生。本文对近年来通过铜死亡参与AD 发病机制的研究进行综述。

Cuproptosis is a newly discovered form of cell death in recent years, while Alzheimer's Disease (AD) is a progressively developing neurodegenerative disorder of the central nervous system with insidious onset. Copper is involved in multiple pathogenic mechanisms of AD, and copper imbalance can induce the death of neurons and glial cells through these distinct mechanisms, thereby contributing to the onset of AD. This review summarizes recent research on the involvement of cuproptosis in the pathogenesis of AD.