卒中是我国居民致死的首位病因，约30%的患者会出现卒中后抑郁（post-stroke depression，PSD）。卒 中的严重程度，类型，病灶的体积、位置和侧别，生活环境，神经递质，神经炎症，神经内分泌功能紊乱，线粒 体功能障碍等均参与了PSD的发生和发展。非药物治疗是PSD的主要治疗方法中的重要一类。本综述总 结了心理治疗、非侵入性脑刺激、电针、深部脑刺激等常规非药物治疗方法的研究进展；重点分析了脑机接 口技术的研究进展，并探讨其在PSD治疗中的潜在治疗价值及发展方向。研究PSD的病理生理机制并研 发新的治疗方法，对改善患者预后有重要临床意义。

Stroke is the leading cause of death among residents in China, with approximately 30% of patients experiencing post-stroke depression (PSD). The severity and type of the stroke, as well as the volume, location, and lateralization of the cerebral lesion, living environment of patients, neurotransmitters, neuroinflammation, neuroendocrine dysfunction, and mitochondrial dysfunction are all implicated in the onset and progression of PSD. Non-pharmacological treatments represent a significant category within the primary treatment methods for PSD. This review summarizes the research progress on conventional non-pharmacological methods such as psychotherapy, non-invasive brain stimulation, electroacupuncture, and deep brain stimulation; it particularly highlights the progress in brain-computer interface technology and discusses its potential therapeutic value and future directions in the management of PSD. Investigating the pathophysiological mechanisms of PSD and developing innovative treatment strategies are of paramount clinical importance for enhancing patient outcomes.