阿尔茨海默病（Alzheimer’s disease，AD）是最常见的痴呆类型，是以进行性认知功能障碍为主要表现 的神经系统退行性病变。调节性细胞死亡是基因决定的细胞主动有序的死亡，普遍存在于在生命体发育过 程中，对调节生命稳态至关重要。随着调节性细胞死亡在AD的广泛研究，越来越多的证据揭示铁死亡与 AD的发生、发展以及转归密切相关。本文将对铁死亡的分子机制及其在AD中的调控作用进行综述，为 AD的发病机制和治疗探索潜在治疗靶点。

Alzheimer’s disease (AD) is the most common type of dementia, characterized by progressive cognitive dysfunction as a primary manifestation of neurodegenerative changes. Regulated cell death, an active and orderly form of cell demise determined by genetic factors, is ubiquitous during the development of living organisms and is crucial for maintaining life homeostasis. With extensive research on regulated cell death in AD, increasing evidence reveals that ferroptosis is closely related to the onset, progression, and outcome of AD. This article will review the molecular mechanisms of ferroptosis and its regulatory role in AD, providing insights into potential therapeutic targets for exploring the pathogenesis and treatment of AD.