目的：对颈内动脉闭塞（ICAO）患者进行5年随访，观察及评估预后情况，并对其影响因素进行分析。 方法：收集 71 例 ICAO 患者作为研究对象，收集患者临床资料；采用电话随访方式随访 5 年，根据改良 Rankin评分（mRS）将ICAO患者分为结局良好组（mRS≤2分）和结局不良组（mRS＞2分）；对可能影响患者 预后的因素进行统计学分析。结果：随访 5 年后，纳入预后良好组 48 例（67.60%），预后不良组 23 例 （32.29%）。坚持口服抗血小板药物（阿司匹林/氯吡格雷）、口服他汀的患者相对预后良好，合并房颤、既往 卒中史，高同型半胱氨酸（HCY）及高胆固醇（TC）血症的患者相对预后不良，2组间差异具有统计学意义 （P＜0.05）。经过Logistic回归分析，口服抗血小板药物（阿司匹林/氯吡格雷）、合并房颤、HCY和TC水平与 ICAO患者预后相关（P＜0.05）。结论：ICAO患者5年的预后总体水平较好。坚持口服抗血小板药物（阿司 匹林/氯吡格雷）的ICAO患者预后相对良好，合并房颤、高HCY和高TC血症的ICAO患者预后不良。

Patients with internal carotid artery occlusion (ICAO) were followed up for 5 years to observe prognosis and analyze patient risk factors. Methods: We collected the clinical data of 71 patients diagnosed with ICAO. Patients received telephone follow-up for 5 years. According to the Modified Rankin Scale (mRS), patients were divided into the good prognosis group (mRS≤2) and poor prognosis group (mRS＞2). Analysis was performed to evaluate the association between certain biomarkers and prognosis. Results: There were 48 cases (67.60%) in the good prognosis group and 23 cases (32.29%) in the poor prognosis group after the 5-year follow-up. Patients who adhered to oral antiplatelet drugs (aspirin/clopidogrel) and oral statin had a better prognosis, while patients with atrial fibrillation, prior stroke history, high homocysteine (HCY), and high cholesterol (TC) had a poorer prognosis, with statistical differences between the two groups (P<0.05). Logistic regression analysis showed that oral antiplatelet drugs (aspirin/clopidogrel), atrial fibrillation, and HCY and TC levels were correlated with prognosis in ICAO patients (P<0.05). Conclusion: The overall prognosis of ICAO patients at 5 years was good. ICAO patients who adhered to oral antiplatelet drugs (aspirin/clopidogrel) had a better prognosis, while those with atrial fibrillation, high HCY, and high TC had a poorer prognosis.