目的：借助功能磁共振成像（fMRI）探讨慢性单侧前庭病变（CUVP）患者的静息态脑自发活动的改变。 方法：右侧CUVP患者18例纳入CUVP组，同期在我院进行健康体检者18例纳入对照组。详细采集入组患 者的病史；行眼震电图、冷热试验等前庭功能评价；行头晕残障量表（DHI）评分；行fMRI检查，计算比率低频 振幅（fALFF），并分析fALFF值与患者临床资料的相关性。结果：与对照组相比，CUVP组患者右侧枕中回 （X=30, Y=－84, Z=3）fALFF值显著降低（P=0.01，FWE校正）；而右侧辅助运动区（X= 9, Y= 3, Z=54）fALFF 值显著升高（P=0.01，FWE 校正）。CUVP 患者右侧枕中回的 fALFF 值与 DHI 评分呈负相关（r=－0.430, P= 0.003），但与CP值和病程均无明显相关性（P=0.833, 0.784）。结论：CUVP患者右侧视觉皮质自发脑功能活动 降低，感觉运动网络自发脑功能活动增高，推测中枢动态代偿不完全可能参与CUVP的发生，CUVP患者的视 觉替代不足，主要依赖于加强姿势控制进行行为替代。

Using fMRI to explore the changes in resting brain spontaneous activity of patients with chronic unilateral vestibulopathy (CUVP). Methods: We recruited 18 patients with right-sided CUVP to the CUVP group and 18 healthy subjects undergoing routine examination at our hospital during the same time period to the control group. Details of disease history were collected. Videonystagmography and bi-thermal caloric testing were performed. Dizziness handicap inventory (DHI) score for all patients were determined. All subjects were further scanned by fMRI. The fractional amplitude of low frequency fluctuation (fALFF) was calculated and analyzed to determine relationship with patient clinical data. Results: Compared with healthy controls, CUVP patients showed lower fALFF values in the right middle occipital gyrus (X=30, Y=－84, Z=3) and higher fALFF values in the right supplementary motor area (X=9, Y=3, Z=54), and the difference was statistically significant (both P=0.01, FWE-corrected). In CUVP patients, the fALFF values in the right middle occipital gyrus were negatively correlated with DHI score (r=－0.430, P=0.003) but showed no significant correlation with CP score nor course of disease (P=0.833, 0.784). Conclusion: In patients with CUVP, spontaneous brain activity was decreased in the visual cortex and increased in the sensorimotor network. It is inferred that the central dynamic compensation may not be completely involved in the occurrence of CUVP; the visual replacement is insufficient, and there is mainly a dependence on the strengthening of posture control.