目的：探索华中地区SREBF1基因突变位点SNP rs11868035与帕金森病（PD）的相关性。方法：本研究 纳入 471 例华中地区原发性 PD 患者和 536 例健康对照者，均为汉族。检测 PD 组和对照组及各亚组间 rs11868035位点等位基因和基因型频率。行文献检索及Meta分析，进一步探索rs11868035位点变异与中国 人群PD易患性的关联。结果：SNP rs11868035位点共3种基因型（AA/AG/GG）；PD组与对照组、各亚组之间 等位基因频率差异、基因型差异无统计学意义（P＞0.05）。Meta分析结果示该位点与中国人群PD发病可能 无明显相关性。结论：华中地区汉族人群SREBF1基因突变位点rs11868035与PD发病可能无相关性。

To explore the correlation of the SREBF1 gene SNP rs11868035 with Parkinson’s disease (PD) in the Han population of central China. Methods: We included 471 patients with idiopathic PD and 536 healthy controls, all of Han ethnicity, in this study, and compared the rs11868035 allele and genotype frequency differences between the two groups. A meta-analysis was conducted to further evaluate the correlation between rs11868035 and the incidence of PD in the Chinese population. Results: There were 3 genotypes (AA/AG/GG) of SNP rs11868035. There was no significant difference in allele frequency nor genotype between the PD group and control group (P>0.05). The meta-analysis showed that there might be no significant correlation between this site and PD incidence in the Chinese population. Conclusion: The SREBF1 gene SNP rs11868035 might not be correlated with the incidence of PD in the Han population of central China.