目的：应用基于体素的度中心度（DC）方法，探讨持续性姿势-感知性头晕（PPPD）患者脑功能网络的 改变。方法：纳入PPPD患者12例及健康受试者12例，均进行静息态功能核磁成像（fMRI），采用基于体素 的DC方法分析fMRI数据，比较PPPD患者与健康受试者的差异。进一步进行相关分析，探讨DC改变与 PPPD患者临床特征的相关性。结果：与健康受试者相比，PPPD患者右侧楔叶、楔前叶（X=12，Y=－84，Z= 21，k=126，P=0.011, FWE校正）DC 值显著降低。 DC 值与 DHI（r=－0.677，P=0.016）、DHI-F（r=－0.581，P= 0.048）、DHI-E（r=－0.690，P=0.013）均呈负相关。结论：PPPD患者楔叶、楔前叶网络节点属性减弱，可能与 患者的持续性头晕不稳及复杂视觉刺激导致症状加重有关。

: To analyze the changes in the brain functional network of persistent postural-perceptual dizziness (PPPD) patients using degree centrality (DC) analysis. Methods: Total 12 PPPD patients and 12 healthy subjects were enrolled for this study and were performed resting-state fMRI scans. The fMRI data were analyzed using a voxel-based DC method, and the differences between PPPD patients and healthy subjects were compared. Further correlation analysis was conducted to investigate the correlation between the DC changes and clinical features in PPPD patients. Results: Compared with that of healthy subjects, the DC value in the right cuneus and precuneus of PPPD patients was significantly lower (X=12, Y=－84, Z=21, k=126, P=0.011, FWE corrected). Correlation analysis revealed that the DC value was negatively correlated with DHI (r=－0.677, P= 0.016), DHI-F (r=－0.581, P=0.048), and DHI-E (r=－0.690, P=0.013) scores. Conclusion: In patients with PPPD, the network hub properties of the cuneus and precuneus are weakened, and this may be related to the patient's persistent dizziness and instability and worsening symptoms due to complex visual stimulation.