目的：分析帕金森病（PD）患者焦虑的临床特征和危险因素。方法：横断面调查PD患者，记录患者 性别、起病年龄、病程、初始症状、改良H-Y分级、MDS-UPDRS-Ⅲ评分、是否伴发不安腿综合征（RLS）、 贝克焦虑量表等临床资料，采用多变量Logistic方法分析PD焦虑的影响因素。结果：共收集263例PD 患者，合并焦虑65例（24.7%），其中女性占36例。病程越长、H-Y分级和MDS-UPDRS-Ⅲ评分更高、伴发 RLS的患者更易发生焦虑（P<0.05），与起病年龄、文化程度、初始症状等方面无明显相关性（P>0.05）。结 论：女性、病程更长、运动功能更严重、合并RLS是PD发生焦虑的危险因素。

To investigate the clinical characteristics of Parkinson's disease (PD) with anxiety and explore its risk factors. Methods: A cross-sectional study of PD patients was carried out in the outpatient department of our hospital and Beijing Tiantan Hospital. The clinical characteristics such as age of onset, disease duration, initial symptoms, modified H-Y stages, MDS-UPDRS-Ⅲ, combination with restless legs syndrome (RLS), and Becker anxiety scale scores were collected. The incidence and influencing factors of anxiety in PD were analyzed by multivariate logistic method. Results: A total of 263 PD patients were included; 65 patients (24.7% ) had anxiety, and 36 of these patients were female. Longer course of disease, higher H-Y stages and MDS-UPDRS- Ⅲ scores, and combination with RLS were positively related with anxiety (P?0.05), but there was no significant correlation between anxiety and the age of onset, education level, or initial symptoms (P ? 0.05). Conclusion: Being female, longer duration of disease, more severe motor function, and combination with RLS are risk factors for PD with anxiety.