目的：探讨颈部动脉迂曲与脑缺血事件首次发病年龄之间的相关性。方法：纳入首次发病的缺血 性卒中（AIS）和短暂性脑缺血发作（TIA）患者135例为脑缺血组，非脑缺血事件患者33例为对照组，所有 患者均完成全脑血管造影（DSA）检查。分别测量2组颈内动脉（ICA）C1段和椎动脉（VA）V1段的迂曲 指数（TI）。使用Spearman秩相关分析颈部动脉TI与脑缺血事件首次发病年龄的关系。结果：在脑缺血 组中，R-ICA C1 段（rs=0.301，P<0.001）、L-ICA C1 段（rs=0.299，P<0.001）、R-VA V1 段（rs=0.382，P<0.001） 和L-VA V1段（rs=0.374，P<0.001）的TI均与发病年龄呈正相关，与男性均呈负相关。在对照组中，颈部 动脉TI中仅有R-VA V1段与年龄呈正相关（rs=0.415，P=0.016），与性别均无明显相关。结论：在脑缺血 事件患者中，首次发病年龄越大，则颈部动脉越迂曲，尤以女性患者较明显。颈部动脉迂曲不能导致脑 缺血事件的首次发病年龄提前。

To investigate the correlation between cervical vessels tortuosity and the age of first onset in cerebral ischemia events. Methods: Clinical data of 168 inpatients was retrospectively analyzed. Of these, 135 patients with first onset of ischemic stroke (AIS) and transient ischemic attack (TIA) were included in the cerebral ischemic events group. The remaining 33 patients with no cerebral ischemic events were included in the control group. All patients underwent digital subtraction angiography (DSA) on cerebral vessels. The tortuosity index (TI) of the C1 segment of the internal carotid artery (ICA) and V1 segment of the vertebral artery (VA) was measured respectively. The Spearman rank correlation coefficient was used to analyze the relationship between cervical vessels tortuosity index and age of first onset of cerebral ischemic events. Results: In the cerebral ischemic events group, the TI of the C1 segment of the right ICA (rs=0.301， P<0.001), C1 of left ICA (rs=0.299，P<0.001), V1 of right VA (rs=0.382，P<0.001), and V1 of left VA (rs= 0.374，P<0.001) were positively correlated with age at first onset and negatively correlated with the male gender. In the control group, only the TI of the right VA V1 segment was positively correlated with age (rs= 0.415, P=0.016), and there was no significant correlation between cervical vessels TI and gender. Conclusion: Increased cervical vessels tortuosity is associated with an increased age at first onset of cerebral ischemic events, and this is more prominent in female patients. Cervical vessels tortuosity does not lead to an earlier age of first onset of cerebral ischemic events.