目的：了解武汉市中心城区居民的抑郁症病耻感程度及其影响因素，为减轻抑郁症病耻感提供有关依 据。方法：多阶段分层整群随机抽取武汉市中心城区1 000 例社区居民，完成一般人口学资料问卷、抑郁症 病耻感量表（DSS）。结果：武汉市中心城区居民抑郁症个人病耻感和感知病耻感检出率分别为21.58%和 48.95% ，感知病耻感总分及7 个条目得分均显著高于个人病耻感（P＜0.05）。年龄、文化程度、婚姻状况、母 亲文化程度对个人病耻感和感知病耻感有显著影响（P＜0.05）。宗教信仰、父亲文化程度影响个人病耻感 （P＜0.05）。性别、民族与个人病耻感和感知病耻感均无显著关系（P＞0.05）。结论：武汉市中心城区居民存 在一定程度的抑郁症病耻感，社会公众感知到的抑郁症病耻感高于个人病耻感，应加强抑郁知识科普宣传， 以减轻公众对抑郁症的歧视和个人对抑郁症的耻感。

To assess the degree and influencing factors of stigma of depression among residents in the urban center of Wuhan and to provide a relevant basis for alleviating the stigma of depression. Methods: One thousand community residents in the urban center of Wuhan were randomly selected by multi-stage stratified cluster, and general demographic data questionnaire and Depression Stigma Scale (DSS) were completed. Results: The detection rates of personal stigma and perceived stigma were 21.58% and 48.95%, respectively, for residents in the urban center of Wuhan. The total score of perceived stigma and 7 items were significantly higher than those of individual stigma (P<0.05). Age, education level, marital status, and mother’s education level significantly influenced personal stigma and perceived stigma (P<0.05). Religion and father’s educational level also influenced individual stigma (P<0.05). Gender and ethnicity had no significant relationship with personal stigma and perceived stigma (P>0.05). Conclusion: There is a certain degree of stigma toward depression among residents in the urban center of Wuhan. The stigma toward depression among the public is higher than that of individuals. Therefore, it is necessary to strengthen the popularization of depression knowledge to alleviate the discrimination of the public against depression and the stigma of individuals against depression.