目的：采用Meta分析探讨卵圆孔未闭（PFO）与偏头痛发病的相关性。方法：计算机检索PubMed、EMbase 、The Cochrane Library、Web of Science、CNKI、VIP、WanFang Data 及CBM数据库，收集观察PFO与偏头 痛发病相关性的病例对照研究或横断面研究或队列研究，检索时限从建库至2018 年8 月1 日。由两名评价 者按照纳入与排除标准筛选文献、提取资料，并进行NOS文献质量评价，采用RevMan 5.3 软件进行Meta 分 析。结果：共纳入30 篇文献，样本量为9 177 例。Meta 分析结果显示偏头痛组与健康对照组PFO发生率差 异有统计学意义（OR=3.19，95%CI 为2.20～4.63，P＜0.01），先兆偏头痛组与健康对照组PFO发生率差异有 统计学意义（OR=3.71，95%CI 为2.13～6.46，P＜0.01），无先兆偏头痛组PFO 发生率高于健康对照组（OR= 1.48，95%CI 为1.09～2.00，P=0.01），先兆性偏头痛组PFO 发生率高于无先兆性偏头痛组（OR=2.32，95%CI 为1.96～2.76，P＜0.01）。PFO组的偏头痛率高于健康对照组（OR=2.58，95%CI 为1.57～4.25，P＜0.01）。结 论：PFO与偏头痛存在明显相关性。

To investigate the correlation between patent foramen ovale (PFO) and migraine using meta-analysis. Methods: The databases of PubMed, EMbase, The Cochrane Library, Web of Science, CNKI, VIP, WanFang Data, and CBM databases were searched to collect case-control studies, cross-sectional studies, or cohort studies that investigated the association between patent foramen ovale and migraine headaches. The retrieval time span was from inception to August 1, 2018. Studies were screened according to inclusion and exclusion criteria, data were extracted, and quality was evaluated by the NOS by 2 reviewers independently. Meta-analysis was conducted using RevMan 5.3 software. Results: A total of 30 articles were included. The sample size was 9177 cases. Meta-analysis showed that there was a statistically significant difference in the incidence of PFO between the migraine group and the healthy control group [OR=3.19, 95% CI (2.20~4.63), P<0.01]. There was statistically significant difference in the incidence of PFO between the migraine with aura group and the healthy control group [OR=3.71, 95%CI (2.13~6.46), P<0.01]. The incidence of PFO in the migraine without aura group was higher than that in the control group [OR=1.48, 95% CI(1.09~2.00), P=0.01]. The incidence of PFO in the migraine with aura group was higher than that in the migraine without aura group [OR=2.32, 95% CI (1.96~ 2.76), P<0.01]. The PFO group had a higher incidence of migraine headaches compared to the healthy control group [OR=2.58, 95% CI (1.57~4.25), P<0.01]. Conclusion: There is a clear correlation between PFO and migraine.