目的：了解80岁及以上高龄高血压患者体位性血压改变与神经退行性并发症的相关性。方法：对28 所三级甲等医院门诊和（或）住院的高血压患者开展联合问卷调查，年龄80～105岁。测量其坐位、卧位和直 立位3 min内血压值，并收集其病史、用药史及生活习惯等相关资料。结果：共1562例纳入本研究。分为体 位性低血压（OH）组387例，非体位性低血压（NOH）组1175例；OH患病率为24.8%（387例）。OH组较NOH 组易并发神经退行性疾病。Logistic回归分析结果显示，阿尔茨海默病及帕金森病与OH的患病率呈正相 关。结论：高龄高血压患者中OH患病率较高，且并发神经退行性疾病的高龄高血压患者易并发OH。

To investigate the correlation between postural blood pressure changes and the complications of neurodegenerative diseases in elderly patients over 80 years old who were diagnosed with hypertension. Methods: A multicenter cross-sectional study was conducted among very old patients (≥80 years) with hypertension using questionnaire-based surveys at 28 Grade A tertiary Hospitals. A total of 1562 subjects aged between 80 and 105 were enrolled in this study. Blood pressures were measured in the sitting position, the supine position and the upright position within 3 minutes of standing. Results: In a total of 1562 subjects, 387 patients were diagnosed with orthostatic hypotension (OH), the other 1175 patients were diagnosed with non-orthostatic hypotension (NOH). The prevalence of OH was 24.8% . OH patients had higher rates suffering from neurodegenerative diseases than NOH patients. The results of a logistic regression analysis indicated that Alzheimer's disease and Parkinson's disease were both positively correlated with the prevalence of OH. Conclusion: The prevalence of OH is high in elderly hypertensive patients over 80 years old. Elderly hypertensive patients complicated with neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease are likely to develop OH.