目的：探讨动脉粥样硬化（AS）与颅内动脉瘤破裂的相关性。方法：颅内动脉瘤患者120例纳入研究， 根据动脉瘤是否破裂分为破裂组99例和未破裂组21例，对其临床及随访资料进行回顾性分析，χ 2 检验分析 颅内动脉瘤发生破裂的相关危险因素及AS与颅内动脉瘤的易感性。结果：颅内动脉瘤是否破裂与患者性 别、个人饮酒和吸烟史、心脑血管疾病既往史、颅内动脉瘤发生部位和颅内动脉瘤的大小有关（P＜0.05）。 颅内动脉瘤患者并发AS与患者具有动脉狭窄、早期的血管内皮损伤及患者体内炎性反应有关（P＜0.05）； 多因素Logistic回归分析结果显示，AS是发生颅内动脉瘤破裂的主要影响因素之一。结论：颅内动脉瘤是 否破裂与患者性别、个人饮酒和吸烟史、心脑血管疾病既往史、颅内动脉瘤的发生部位和大小有关；AS可能 与颅内动脉瘤破裂具有一定的相关性。

To investigate the correlation between atherosclerosis (AS) and intracranial aneurysm rupture. Methods: One hundred and twenty cases with intracranial aneurysm were included, which were divided into ruptured group (n=99) and unruptured group (n=21). Clinic data was collected and retrospectively analyzed. The related risk factors of intracranial aneurysms rupture were analyzed by χ 2 test. The correlation between AS and intracranial aneurysm rupture was analyzed. Results: The gender, personal history of drinking and smoking, history of cardiovascular and cerebrovascular diseases, and the sites and the size of intracranial aneurysms were the risk factors for intracranial aneurysm rupture (P<0.05). AS was more likely to be detected in intracranial aneurysm patients with arteriostenosis, early vascular endothelial injury and inflammatory response (P<0.05). Multivariate logistic regression analysis results showed that AS was one of the main factors influencing the rupture of intracranial aneurysms. Conclusion: The gender, personal history of drinking and smoking, history of cardiovascular and cerebrovascular diseases, and the site and the size of intracranial aneurysms were the risk factors for intracranial aneurysm rupture. AS may be associated with intracranial aneurysm rupture.