目的：探讨不同性别青少年精神分裂症患者经抗精神病药物治疗4周前后体质量、空腹血糖（FBG）、 血尿酸（UA）和血脂代谢的变化。方法：纳入住院治疗的青少年精神分裂症患者186例，男88例，女98例。 给予相应的抗精神病药物治疗4周。比较治疗前、后患者体质量、血UA、甘油三酯（TG）、总胆固醇（TC）、低 密度脂蛋白（LDL）和高密度脂蛋白（HDL）水平及其变化。结果：与治疗前相比，女性青少年治疗4周后体质 量、TG、LDL增高（P＜0.05），FBG、TC、UA、HDL的血清水平，高TG血症的发生率和高UA血症发生率差异 无统计学意义（P＞0.05）；男性青少年治疗4周后体质量，TG、LDL、UA的血清水平，高TG血症发生率增高 （P＜0.05），FBG、TC、HDL 的血清水平，高 UA 血症的发生率差异无统计学意义（P＞0.05）；治疗 4 周后 15.30%的女性青少年和15.91%的男性青少年体重增加了7%。结论：抗精神病药物治疗对青少年精神分裂 症患者血脂和血UA代谢有影响，尤其是男性患者。

To explore the changes in weight, fasting blood glucose (FBG), serum uric acid (UA), and lipid metabolism among adolescent schizophrenia patients of different sexes after 4-week treatment with atypical antipsychotic agents. Methods: One-hundred and eighty-six adolescent schizophrenia inpatients (88 males and 98 females) were involved in the study. Patients were treated with appropriate antipsychotic medication for 4 weeks. Weight, FBG, UA, triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL), and high-density lipoprotein (HDL) were measured before and after treatment, and the levels were compared. Results: In female patients, compared with baseline, a significant increase in weight, TG, and LDL was observed after treatment (P<0.05), and no significant difference was observed in FBG, TC, UA, HDL, and the incidence of hypertriglyceridemia and hyperuricemia (P>0.05). In male patients, compared with baseline, a significant increase in weight, TG, LDL, UA, and the incidence of hypertriglyceridemia was observed after treatment (P<0.05), and no significant difference was observed in FBG, TC, HDL, and the incidence of hyperuricemia (P>0.05). The weight of 15 female patients (15.30%) and the weight of 14 male patients (15.91%) increased 7% compared with those before treatment. Conclusion: Atypical antipsychotic agents have a certain affection on lipid and uric acid metabolism in adolescent schizophrenia, especially in male patients．