目的：研究血清细胞因子水平对癫痫合并抑郁的影响。方法：癫痫患者766例纳入研究，进行问卷调 查、Beck抑郁量表-II（BDI-II）评分、癫痫相关的耻辱感量表评分、血清细胞因子水平测量，并对相关数据进 行统计学分析。结果：本组癫痫患者中抑郁症的患病率为30.3%，其中，轻、中、重症分别为41.3%、34.4%和 24.3%。多因素Logistic回归结果显示，在校正了其他混杂因素之后，血清IL-6第2、3、4分位组相对于第1分 位组是癫痫合并抑郁的危险因素，血清IL-10第2、3、4分位组相对于第1分位组是癫痫合并抑郁的保护因 素。结论：高 IL-6水平可能是癫痫合并抑郁的危险因素，高IL-10水平可能是癫痫合并抑郁的保护性因素。

To explore the relationship between serum cytokines and depression in epilepsy. Methods: A total of 766 patients diagnosed with epilepsy were selected for the study. Patients were evaluated by questionnaire and assessed using the Beck Depression Inventory-II (BDI-II) scale and epilepsy-related stigma score, and serum cytokine levels were measured. The data obtained were analyzed for statistical significance. Results: The prevalence of depressive disorder among patients with epilepsy was 30.3% . Of these, 41.3% , 34.4%, and 24.3% of patients were found to have mild, moderate, and severe depression, respectively. Logistic regression analysis showed that after correcting for confounding factors, compared with the first group of interleukin-6 (IL-6), the second, third, and fourth groups were risk factors for depression combined with epilepsy. On the other hand, compared with the first group of interleukin-10 (IL-10), second, third, and fourth groups were protective factors for depression combined with epilepsy. Conclusion: High level of IL-6 may be a risk factor for the incidence of depression in epilepsy. High level of IL-10 may be a protective factor for the incidence of depression in epilepsy