目的：探讨急性缺血性卒中患者应用丁苯酞（NBP）治疗对早期痫性发作的预防作用。方法：回顾性总 结1 046例急性缺血性卒中患者临床资料，按是否接受NBP治疗分为NBP组584例和对照组462例，比较2 组在卒中发病14 d内痫性发作的差异。采用多因素Logistic回归分析法分析急性缺血性卒中合并早期痫性 发作的影响因素。结果：NBP组早期痫性发作的发病率低于对照组（3.4% v.s. 5.6%，P=0.030）。大面积脑梗 死（OR=3.451，95%CI 1.742~8.160，P=0.007）、入院时NIHSS评分≥15分（OR=3.002，95%CI 1.521~6.872，P= 0.013）和梗死灶涉及脑叶（OR=2.030，95%CI 1.143~3.482，P=0.021）是缺血性卒中患者发生痫性发作的危险 因素，接受NBP治疗（OR=0.672，95%CI 0.461~0.870，P=0.033）是痫性发作的保护性因素。结论：NBP治疗 可能有效预防急性缺血性卒中患者早期痫性发作。

To explore the preventive effect of dl-3-n-butylphthalide (NBP) on early seizures in patients of acute ischemic stroke. Methods: This study retrospectively analyzed data from 1 046 patients with acute ischemic stroke. Patients were divided into groups NBP(n=548) or control(n=462) based on whether received NBP treatment. The two groups were compared for differences in morbidity of early seizures occurring within 14 days of acute ischemic stroke. Multivariable logistic regression analysis was applied to analyze risk factors of early seizures after acute ischemic stroke. Results: The morbidity of early seizures after acute ischemic stroke in the NBP group was significantly lower than that of the control group (3.4% vs. 5.6%, P=0.030). Massive cerebral infarct size (OR=3.451, 95%CI 1.742~8.160, P=0.007), NIHSS score on admission being≥15 points (OR=3.002, 95%CI 1.521~6.872, P=0.013), and lobar infarct location (OR=2.030, 95%CI 1.143~3.482, P= 0.021) were risk factors of early seizures after acute ischemic stroke, whereas receiving NBP treatment (OR= 0.672, 95%CI 0.461~0.870, P=0.033) was a protective factor for early seizures. Conclusion: NBP could effectively prevent early seizures in patients of acute ischemic stroke.