支链氨基酸（branched-chain amino acids，BCAAs）作为必需氨基酸，其与神经退行性疾病（neurode
generative disease，NDD）的发生发展密切相关。近年来研究发现，BCAAs 代谢异常与NDD的发生、进展及
预后密切相关。本文综述了 BCAAs在NDD中的代谢特征，以及其通过调节信号通路、改善线粒体功能障
碍、减轻神经炎症以及调控表观遗传学等参与NDD发生与发展的过程的机制，期望为深入研究 BCAAs在
NDD中的具体作用机制，以及为临床精准治疗NDD提供更多依据。
Branched-chain amino acids (BCAAs), as essential amino acids, are closely associated with the onset
and progression of neurodegenerative diseases (NDDs). Recent studies have revealed that abnormal BCAAs
metabolism is intricately linked to the occurrence, progression, and prognosis of NDDs. This review summarizes
the metabolic characteristics of BCAAs in NDDs and the mechanisms by which they participate in the onset and
development of NDDs through regulating signaling pathways, ameliorating mitochondrial dysfunction,
alleviating neuroinflammation, and modulating epigenetics. It is hoped that this will provide further insights into
the specific mechanisms of BCAAs in NDDs and offer more evidence for precise clinical treatment of NDDs.
PDF(672 KB)
