脊髓损伤（spinal cord injury，SCI）是一种常见的中枢神经系统损伤，会导致患者瘫痪甚至死亡，给社 会带来了沉重的医疗负担。SCI的过程中会发生多种调节性细胞死亡（regulated cell death，RCD），如细胞 凋亡、细胞自噬、细胞焦亡和细胞铁死亡等。活性氧（reactive oxygen species，ROS）是细胞代谢中氧不完全 还原时产生的分子或自由基，在SCI过程中，ROS通过各种机制调控RCD，影响SCI的预后。本文综述近 年来ROS在SCI中调控RCD的机制。

Spinal cord injury (SCI) is a common neurotraumatic damage, which may lead to paralysis or even death in patients and impose a significant medical burden on society. Various forms of regulated cell deaths (RCD), such as apoptosis, autophagy, pyroptosis, ferroptosis and so on, occur during the process of SCI. Reactive oxygen species (ROS), molecules or free radicals produced during incomplete reduction of oxygen in cellular metabolism, regulate RCD through various mechanisms in SCI, thereby influencing its prognosis. This paper reviews the mechanisms by which ROS regulate RCD in SCI in recent years.